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SARS-CoV-2 uses the angiotensin-converting enzyme ( ACE ) 2 receptor for entry into target cells. ACE2 is predominantly expressed by epithelial cells of the lung, intestine, kidney, heart, and blood ...


The objective of a study was to delineate the clinical characteristics of patients with coronavirus disease 2019 ( Covid-19 ) who died. Among a cohort of 799 patients, 113 who died and 161 who reco ...


Coronavirus disease 2019 ( COVID-19 ) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments. The objective of a study was to determine ...


The coronavirus disease 2019 ( COVID-19 ) virus, emerged in December 2019, has spread rapidly, with cases now confirmed in multiple countries. As of February 16, 2020, the virus has caused 70,548 in ...


A cluster of patients with coronavirus disease 2019 ( COVID-19 ) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ) were successively reported in Wuhan, ...


In December 2019, a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan, a city of 11 million people in central China. The initial cases were linked to exposures in a seafood ma ...


The experimental antiviral Remdesivir has successfully prevented disease in rhesus macaques infected with Middle East respiratory syndrome coronavirus ( MERS-CoV ), according to a new study from Natio ...


In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease ( EVD ) in 286 patients. The cycle threshold ( Ct ) of an Ebola virus-specific reverse transcr ...


Results from a phase 1 study evaluating the pharmacokinetics and safety of a prototype subdermal drug-eluting implant for extended administration of Islatravir, a nucleoside reverse transcriptase tran ...


Week 48 results from phase III TANGO study were announced. The TANGO study was conducted to assess whether adults living with HIV-1 who had maintained viral suppression for at least six months on a Te ...


Integrase strand transfer inhibitor ( INSTI ) resistance profiles and factors associated with resistance in antiretroviral-naive and -experienced patients failing an INSTI-based regimen in clinical pr ...


The aim of a study was to expand understanding of the virological potency of initial Dolutegravir plus Lamivudine dual therapy ( Dolutegravir / Lamivudine; Dovato ). Researchers have compared the vir ...


The FDA ( US Food and Drug Administration ) has approved a new drug for the treatment of influenza. Baloxavir marboxil ( Xofluza ) works against the two types of influenza virus that cause disease in ...


Human coronaviruses ( HCoVs ) -OC43, -229E, -NL63 and -HKU1 cause upper and lower respiratory tract infections. HCoVs are globally distributed and the predominant species may vary by region or year. ...


Immunotherapy has been a major breakthrough in oncology, but little is known about its safety for HIV-positive cancer patients. A study, presented at the ESMO 2018 Congress in Munich, has now provid ...